Lectureship Award MBLA Winners

Japanese

“MBLA 2016”

Dr. Tomoki Ogoshi

Winner
Dr. Tomoki Ogoshi
(Professor, Graduate School of Natural Science and Technology, Kanazawa University)

Research subject
Synthesis of Pillar-Shaped Macrocyclic Compounds “Pillar[n]arenes” Providing Supramolecular Assemblies

研究概要

構造式
Dr. Ogoshi has developed a new class of macrocyclic hosts named “pillar[n]arenes”. They have unique symmetrical pillar structures due to their para-bridge linkage. Linear 1,2-dichloroethane and bulky chlorocyclohexane acted as template solvents for high-yield synthesis of pillar[5]- and pillar[6]arenes, respectively. Dr. Ogoshi has synthesized various topological and functional molecules based on functionality of pillar[n]arenes, and constructed 2D sheets and 3D vesicles based on geometric assemblies of their pentagonal and hexagonal structures.

 

“MBLA 2015”

Dr. Satoshi Maeda

Winner
Dr. Satoshi Maeda
(Associate Professor, Department of Chemistry, Faculty of Science, Hokkaido University)

Research subject
Development of Automated Reaction Path Search Methods toward Systematic Understanding and Design of Organic Reactions

研究概要

構造式
The geometry optimization has become a powerful tool to study mechanisms of chemical reactions theoretically. However, it requires some guesses about the mechanism. To study highly complicated multistep mechanisms and reactions for which few previous knowledge is available, fully automated methods that can find both expected and unexpected pathways have been desired. Dr. Maeda has worked on development of such theoretical approaches. His methods have been utilized in studies of a variety of chemical reactions for systematic understanding of their reaction mechanism, selectivity, optical response, etc.

 

“MBLA 2014”

Dr. Jun Takaya Winner
Dr. Jun Takaya
(Associate Professor, Graduate School of Science and Engineering, Tokyo Institute of Technology)
Research subject
Development of New Synthetic Reactions Catalyzed by a Transition Metal Complex Featuring Fluxional Behavior of a Silyl-Ligand

研究概要

構造式
Development of multi-functional ligand for transition metal catalyst is an important challenge to achieve efficient synthetic transformations of unreactive molecules. Dr. Takaya has developed new synthetic reactions of carbon dioxide and unsaturated hydrocarbons utilizing newly designed palladium catalysts bearing a group 14 element-centered pincer ligand. Mechanistic investigations clarified intermediacy of an unprecedented η2-(Si–H)Pd(0) complex through fluxional behavior of the silyl ligand, which enables unprecedented bond activation/formation mechanisms.

 

“MBLA 2013”

Dr. Daisuke Uraguchi Winner
Dr. Daisuke Uraguchi
(Associate Professor, Graduate School of Engineering, Nagoya University)
Research subject
Development of chiral organic ion pair catalysts for controlling reactive ionic intermediates

研究概要

構造式
Controlling anionic species by counterions is simplest yet difficult strategy in synthetic chemistry due to ambiguous distance and angle between anions and cations. Dr. Uraguchi has demonstrated that anionic intermediates could be precisely controlled by chiral organic cations through cooperative exploitation of electrostatic and hydrogen-bonding interactions to form “structured ion pair”. Highly chemo- and stereoselective transformations were developed under the unique catalyses of P-spiro aminophosphonium salts and ammonium betaines.

 

“MBLA 2012”

Dr. Mamoru Tobisu Winner
Dr. Mamoru Tobisu
(Associate Professor, Graduate School of Engineering, Osaka University)
Research subject
Catalytic Transformations of Strong σ-Bonds

研究概要

構造式
The use of strong chemical bonds in catalytic reactions represents a formidable challenge in pure chemistry and would also be beneficial in applied chemistry for enabling strategic diversity in organic synthesis. Dr. Tobisu has developed a series of catalytic reactions that can directly transform inert carbon‒oxygen, carbon‒cyano and carbon‒silicon bonds into an array of useful compounds.

 

“MBLA 2011”

Dr. Ryo Shintani Winner
Dr. Ryo Shintani
(Associate Professor, Graduate School of Engineering, The University of Tokyo)
Research subject
Selective Synthesis of Cyclic Compounds under Transition Metal Catalysis

研究概要

構造式
Dr. Shintani designed and utilized new organic reagents for palladium-catalyzed stereoselective intermolecular addition/cyclization reactions, highlighting efficient generation and use of zwitterionic π-allylpalladium intermediates bearing pendant nucleophilic sites. This method allows for the preparation of a diverse array of carbo- and heterocycles that are difficult to synthesize with existing methods, and mechanistic studies on these catalytic reactions have also been successfully carried out.

 

“MBLA 2010”

Dr. Shigeki Matsunaga Winner
Dr. Shigeki Matsunaga
(Professor, Graduate School of Pharmaceutical Sciences, Hokkaido University)
Research subject
Development of Multimetallic Concerto Asymmetric Catalysis Using Multidentate Chiral Ligands

研究概要

構造式
On the basis of the unique design of multi-nucleating chiral ligands, Dr. Matsunaga has developed various types of multimetallic complexes for bifunctional asymmetric catalysis. The suitably aligned metal centers function in concerted fashion, promoting catalytic asymmetric carbon-carbon bond-forming reactions and other reactions in high enantioselectivity. Detailed mechanistic studies as well as synthetic applications to biologically active compounds have also been achieved.

 

“MBLA 2009”

Dr. Yoshiaki Nakao Winner
Dr. Yoshiaki Nakao
(Professor, Graduate School of Engineering, Kyoto University)
Research subject
C-C Bond Forming Addition Reactions by Cooperative Metal Catalysis

研究概要

構造式
Dr. Nakao has developed new C-C bond forming addition reactions through activation of stable C-H and C-C bonds by cooperative metal catalysis. The achievements involve carbocyanation reactions of unsaturated compounds through activation of C-CN bonds of nitriles by nickel/Lewis acid cooperative catalysis. Hydroarylation and hydrocarbamoylation reactions are also effected by the binary catalysis through C-H activation of pyridines, pyridones, and formamides.

 

“MBLA 2008”

Dr. Ken Ohmori Winner
Dr. Ken Ohmori
(Associate Professor, Graduate School of Science and Engineering, Tokyo Institute of Technology)
Research subject
Synthetic Study on Polycyclic Bioactive Natural ProductsTechnical Achievement

研究概要

構造式
Dr. Ohmori has developed novel synthetic approaches to densely functionalized polycyclic framework embedded in various bioactive natural products. One of major challenges is the total synthesis of the benanomicin-pradimicin antibiotics via the stereo-selective/specific pinacol cyclization transmitting the stereochemical information from an axial to centrals. This approach would serve as a general and practical synthetic way for highly-oxygenated polycyclic natural/unnatural compounds.

 

“MBLA 2007”

Dr. Kenichiro Itami Winner
Dr. Kenichiro Itami
(Professor, Graduate School of Science, Nagoya University)
Research subject
Creation of Functional Materials Based on Catalytic Direct Functionalization of Olefins and Aromatics

研究概要

構造式
Dr. Itami has developed a number of transition-metal-based catalytic methods that permit efficient functionalization (mainly C-H bond functionalization) of olefins, aromatics, and nano-carbons. These direct and programmable synthetic methodologies not only led to the generation of a number of optoelectronic organic materials and bioactive compounds, but also unlocked opportunities for markedly different strategies in chemical synthesis.

 

“MBLA 2006”

Dr. Jun Terao Winner
Dr. Jun Terao
(Associate Professor, Graduate School of Engineering, Kyoto University)
Research subject
New Methodologies for Carbon-Carbon and Carbon-Silicon Bond Forming Reactions Using Anionic Transition Metal Complexes as Active Catalytic Species

研究概要

構造式
Dr. Terao has developed new methodologies for carbon-carbon and carbon-silicon bond forming reactions using alkyl halides and/or chlorosilanes by drawing focus to these characteristics of an anionic complex. This study will open up a new field of transition metal chemistry providing a unique methodology for introduction of alkyl and silyl groups across carbon-carbon unsaturated units.

 

“MBLA 2005”

Dr. Motomu Kanai Winner
Dr. Motomu Kanai
(Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Research subject
Development of Catalytic Enantioselective Carbon-Carbon Bond-Forming Reactions: Chirality Control for Tetrasubstituted Carbons

研究概要

構造式
Dr. Kanai's achievement is the development of Lewis acid-Lewis base bifunctional asymmetric catalysis and soft metal-hard anion conjugated asymmetric catalysis.

 

“MBLA 2004”

Dr. Masayuki Inoue Winner
Dr. Masayuki Inoue
(Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Research subject
Total Synthesis of Neuromodulatory Natural Products

研究概要

構造式
Dr. Inoue's achievement is the development of efficient methods and strategies for total synthesis of structurally complex and biologically significant natural products such as TMC-95A, merrilactone A, and ciguatoxins.